Abstract: Cutaneous melanoma incidence and survival among U.S. blacks, Further elucidation of risk factors for cutaneous melanoma in blacks and APIs and. Abstract: Romidepsin is a histone deacetylase inhibitor recently approved by the FDA for the treatment of cutaneous T-cell lymphoma. It has led to protracted. Diabetes is the most common endocrine disorder, affecting % of the population (1). Skin disorders will be present in % of people with diabetes (2) .

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Although negative predictive value was excellent 0. It is the second most common skin manifestation in people with diabetes. Although NL is benign, its appearance is cosmetically distressing to patients Fig. Telangectasias arise in the nail beds of people with diabetes after loss of capillary loops and dilation of remaining capillaries.

This condition is seen more often in men and in those with longstanding peripheral neuropathy. J Am Med Inform Assoc. EX lesions tend to resolve spontaneously within weeks Bacterial Infections Cutaneous bacterial infections are more common, as well as more severe, in people with diabetes.

Diabetes mellitus and other endocrine diseases. The appearance of RF correlates with poor glucose control.

Acquired Perforating Dermatosis Acquired perforating dermatosis presents as dome-shaped papules and nodules with hyperkeratotic plugs. The pathophysiology of EN is under-investigated.

Acanthosis nigricans AN is likely the most readily recognized skin manifestation of diabetes 3. Most people with psoriasis will be treated by a dermatologist. Dermatologists often make the diagnosis of diabetic bulla; after diagnosis, this condition can be managed by PCPs. Heredity, obesity, endocrine disorders, certain drugs, and malignancy are associated with AN.


Recent research shows that psoriasis may raise predisposition for developing diabetes mellitus, just as it does for heart attack and stroke. Most conditions can be managed by PCPs, but cutsneous to a dermatologist may be warranted in some cases. Skin manifestations of diabetes. Clinical variants of lichen planus. This condition is often fatal.

Cutaneous Manifestations of Diabetes Mellitus

Significant weight loss resolves AN type 2 and type 3. Epidermal necrolysis Stevens—Johnson syndrome and cutaneus epidermal necrolysis. Cutaneous disorders in diabetic patients attending diabetic clinic. Levy L, Zeichner JA. Current treatments include withdrawal of all medications that would not be life-threatening.

In a study of people with diabetes compared with control subjects, the most common infection in people with diabetes was tinea pedis, followed by distal subungual onychomycosis J Dtsch Dermatol Ges ; Am Fam Phys ; The pathogenesis of GA is currently unknown.

Periungual Telangectasias Periungual telangectasias present as nail fold erythema, dilated blood vessels ccutaneous to the naked eye, riletype tenderness, and thick cuticles. Lesions resolve on their own in 2—5 weeks.

Glycemic control has no effect on the course of NL The psychosocial impact of vitiligo can be substantial, and patient support groups fjletype available. Int Arch Med ; 1: Onychodystrophy presents as excessive nail thickening and deformity, which may cause accumulation of debris and subsequent infection of the toe that should be treated as a diabetic ulcer.

Cutaneous Manifestations of Diabetes Mellitus

Scleredema diabeticorum successfully treated with ultraviolet A1 phototherapy. Calcipotriol, topical PUVA, excimer laser, corticosteroid pulse therapy, and surgical melanocyte grafting are some of the treatment options.


Please review our privacy policy. Clin Exp Dermatol ; Eruptive Xanthoma Eruptive xanthoma EX presents on the buttocks, elbows, and knees as sudden onset crops of yellow papules with an erythematous base Fig.

Vitiligo Vitiligo affects 0.

On cadaveric skin biopsy, 4 of 14 samples demonstrated moderate to severe arterial wall thickening, and 11 of 14 samples demonstrated mild basement membrane thickening. Microscopically, AN presents as papillomatosis and hyperkeratosis epidermis in irregular folds, exhibiting various degrees of acanthosis.

Malignant external otitis media requires immediate recognition and systemic antibiotics such as fluoroquinolones, plus an antipseudomonal antibiotic e. Prevalence and significance of acanthosis nigricans cktaneous an adult obese population.

Med Hypotheses ; Pseudomonas aeruginosa is another common diabetic foot ulcer organism. Tinea corporis, tinea pedis Fig. Severe adverse cutaneous reactions to drugs. Treatments have showed limited benefits.

The sudden appearance of EX can be worrisome to patients and may prompt a visit to the physician. Psoriasis is a chronic, inflammatory, polygenic skin disorder with environmental triggers such as trauma, medications, and infection. Differential diagnosis includes bullous pemphigoid, which can be ruled out by submitting a biopsy of the lesion for direct and indirect immunofluorescence.

Possible etiologies are both environmental and polygenetic.